REDEFINING THE RETINOID PATHWAY: UNLEASHING THE POWER OF FIRST-IN-CLASS ORAL INHIBITORS
KayoThera specializes in pioneering a novel class of safe oral antagonists that are the first of their kind to target retinoid signaling. Previously considered “undruggable,” the retinoid pathway has posed challenges to drug development for nearly three decades. Past clinical experience with retinoid pathway activators has revealed two consistent findings among thousands of patients: adverse outcomes in solid cancers and a range of cardiometabolic effects, from hyperlipidemias to insulin resistance.
In response, KayoThera has developed a comprehensive pipeline of drugs focused on inhibiting retinoid signaling based on new biological insights to the pathway. The lead program in oncology aims to target retinoid synthesis in immune cells, while the cardiometabolic program concentrates on inhibiting retinoids in the pancreas, muscle, and fat-storing tissues. By pursuing this innovative approach, KayoThera aims to address critical medical needs and potentially revolutionize the treatment landscape in both oncology and cardiometabolic diseases.
KayoThera founders publish Nature Cancer review on new therapeutic strategies to treat incurable cancers
Announcing a new review on emerging strategies to treat advanced cancers published in Nature Cancer.
In the cover article of the March issue of Nature Cell Biology, Dr. Mark Esposito and Dr. Yibin Kang announce the discovery of a novel driver of breast and prostate cancer metastasis. This newly discovered organelle is driven by a relatively unknown protein named...
KayoThera will be presenting at this year's 10th Annual BioNJ Biopartnering Conference. Please join us Tuesday, October 6 & Wednesday, October 7, 2020.
Kayothera, an early-stage therapeutics company and Princeton University spinout, is working to give hope to some of the most vulnerable cancer patients. Now the company’s aspirations are being bolstered by significant seed funding received from the New Jersey Health...